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Pentose phosphate pathway / Phosphogluconate pathway Hexose monophosphate shunt. It is a metabolic pathway, parallel to glycolysis. It occurs in cytosol It generates NADPH and pentoses (5-carbon sugars) as well as Ribose 5-phosphate (a precursor for the synthesis of nucleotides). This pathway consist of two phases: 1. Irreversible oxidative phase involves generation of NADPH. 2. Reversible non oxidative phase involves interconversion of sugars. 1 1. In the oxidative phase, NADPH is generated when glucose 6-phosphate is oxidized to ribulose 5-phosphate. NADPH production is important for: (a)Biosynthesis of fatty acids, neurotransmitters, cholesterol and nucleotides; (b)detoxification of glutathione (reduced glutathione due to NADPH helps to prevent the oxidation of Fe (II) to Fe (III) in hemoglobin. Hemoglobin containing Fe (III) is not effective in binding O2) and cytochrome P450 monooxygenase. 2 3 4 5 6 7 Name: Description: ...
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