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Eculizumab

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HCAS143 Human Diseases and Pharmacology
Brand Name of Drug
SOLIRIS
Generic Name
eculizumab
Drug Class
Monoclonal Antibodies
Used for Treatment of
patients with a disease called Paroxysmal Nocturnal Hemoglobinuria (PNH).
adults and children with a disease called atypical Hemolytic Uremic Syndrome (aHUS).
SOLIRIS is not for use in treating people with Shiga toxin E. coli related hemolytic uremic
syndrome (STEC-HUS).
adults with a disease called generalized myasthenia gravis (gMG) who are anti-
acetylcholine receptor (AchR) antibody-positive
adults with a disease called neuromyelitis optica spectrum disorder (NMOSD) who are anti-
aquaporin-4 (AQP4) antibody positive
Side Effects
headache,
tiredness,
nausea,
vomiting,
diarrhea,
muscle pain,
back pain, or
cold symptoms such as stuffy nose, sneezing, or sore throat
Key Facts
(Warnings, If you miss a dose,
etc)
You should not use this medicine if you have bacterial meningitis or if you have not been
vaccinated against meningitis.
Eculizumab affects your immune system. You may get infections more easily, even serious
or fatal infections.
You must be vaccinated against meningococcal infection at least 2 weeks before treatment
with eculizumab.
Seek emergency medical attention or call your doctor right away if you have symptoms of
meningitis: headache and fever with nausea or vomiting, skin rash, body aches, flu
symptoms, confusion, sensitivity to light, stiffness in your neck or back.
Do not stop receiving eculizumab without first talking to your doctor. Stopping or
interrupting your treatment could cause sudden and serious effects on your red blood cells.
This medication is used to treat Myasthenia gravis a chronic autoimmune disorder in which the body attacks its
own neuromuscular connections. This causes problems with communication between nerves and muscle, resulting in
weakness. Myasthenia gravis affects the voluntary muscles of the body, especially the eyes, mouth, throat, and
limbs.
Myasthenia gravis develops later in life when antibodies in the body attack normal receptors on muscle. This blocks
a chemical needed to stimulate muscle contraction
I choose this medicine because my Uncle has myasthenia gravis and although I am not sure what medication he is
taking this is the first one I found that is used to treat this condition.

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HCAS143 – Human Diseases and Pharmacology Brand Name of Drug SOLIRIS Generic Name eculizumab Drug Class Monoclonal Antibodies Used for Treatment of patients with a disease called Paroxysmal Nocturnal Hemoglobinuria (PNH). adults and children with a disease called atypical Hemolytic Uremic S ...
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