Week 3: Discussion: Pharmacotherapy for Cardiovascular Disorders As the leading cause of death in the United States for both men and women, cardiovascular disorders account for 7 million hospitalizations per year (NCSL, 2012). This is the result of the extensive treatment and care that is often required for patients with these disorders. While the incidences of hospitalizations and death are still high, the mortality rate of cardiovascular disorders has been declining since the 1960s (CDC, 2011). Improved treatment options have contributed to this decline, as well as more knowledge on patient risk factors. As an advanced practice nurse, it is your responsibility to recommend appropriate treatment options for patients with cardiovascular disorders. To ensure the safety and effectiveness of drug therapy, advanced practice nurses must consider aspects that might influence pharmacokinetic and pharmacodynamic processes such as medical history, other drugs currently prescribed, and individual patient factors. Consider the following case studies: Case Study 1: Patient AO has a history of obesity and has recently gained 9 pounds. The patient has been diagnosed with hypertension and hyperlipidemia. Drugs currently prescribed include the following: Atenolol 12.5 mg dailyDoxazosin 8 mg dailyHydralazine 10 mg qidSertraline 25 mg dailySimvastatin 80 mg daily Case Study 2: Patient HM has a history of atrial fibrillation and a transient ischemic attack (TIA). The patient has been diagnosed with type 2 diabetes, hypertension, hyperlipidemia and ischemic heart disease. Drugs currently prescribed include the following: Warfarin 5 mg daily MWF and 2.5 mg daily T, TH, Sat, SunAspirin 81 mg dailyMetformin 1000 mg po bidGlyburide 10 mg bidAtenolol 100 mg po dailyMotrin 200 mg 1–3 tablets every 6 hours as needed for pain Case Study 3: Patient CB has a history of strokes. The patient has been diagnosed with type 2 diabetes, hypertension, and hyperlipidemia. Drugs currently prescribed include the following: Glipizide 10 mg po dailyHCTZ 25 mg dailyAtenolol 25 mg po dailyHydralazine 25 mg qidSimvastatin 80 mg dailyVerapamil 180 mg CD daily To prepare: Review this week’s media presentation on hypertension and hyperlipidemia, as well as Chapters 19 and 20 of the Arcangelo and Peterson text.Select one of the three case studies, as well as one the following factors: genetics, gender, ethnicity, age, or behavior factors.Reflect on how the factor you selected might influence the patient’s pharmacokinetic and pharmacodynamic processes.Consider how changes in the pharmacokinetic and pharmacodynamic processes might impact the patient’s recommended drug therapy.Think about how you might improve the patient’s drug therapy plan based on the pharmacokinetic and pharmacodynamic changes. Reflect on whether you would modify the current drug treatment or provide an alternative treatment option for the patient. With these thoughts in mind: Post an explanation of how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you selected. Then, describe how changes in the processes might impact the patient’s recommended drug therapy. Finally, explain how you might improve the patient’s drug therapy plan.

Assignment 1: Financial Statement / Audit Report ReviewDue Week 4 and worth 240 pointsSelect one (1) local government in your state or area and review the financial statements and audit report for the county or municipality. The financial statements of the government you selected should have at least three (3) funds. Refer to the continuing problem homework for Weeks 1 through 3 for this assignment.Write a three to five (3-5) page paper in which you:1. Compare and contrast the comprehensive annual financial report (CAFR) of the selected local government entity with the government entity identified from Week 1 homework. In your comparison, include: a. Publication method of the CAFR b. Audit and budget information in the CAFRc. The type of audit report issuedd. Existence or non-existence of an internal audit function within the government entity2. Prepare the analysis for the selected local government entity, including information on the introduction, financial section, and statistical section prepared in the continuing problem CAFR from chapter 2. 3. Analyze the methods used by the selected local government entity in comparing the budget-to-actual reports. Your analysis should include an evaluation of the basis of accounting used for the budget and financial statements.4 .Analyze the sources of revenue on the selected local government. Your analysis should include information on both governmental and business-type activities of the government. In your report, be sure to examinea. Property taxes and how they are accounted forb. Other sources identified as primary revenue for the entityc. Deferred revenued. Year-to-year variations in the tax levels of incomee. Various management discussion and analysis items of notef. Information about the general fundYour assignment must follow these formatting requirements:Be typed, double spaced, using Times New Roman font (size 12), with one-inch margins on all sides; citations and references must follow APA or school-specific format. Check with your professor for any additional instructions.Include a cover page containing the title of the assignment, the student’s name, the professor’s name, the course title, and the date. The cover page and the reference page are not included in the required assignment page length.The specific course learning outcomes associated with this assignment are:Evaluate the financial reporting of state and local governments and assess the reporting requirements in accordance with governmental accounting standards board (GASB). Analyze governmental activities related to expenditures and expenses.Use technology and information resources to research issues in government and not-for-profit accounting.Write clearly and concisely about government and not-for-profit accounting using proper writing mechanics.