Central nervous system and drugs acting on it

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NERVOUS SYSTEM AND DRUGS ACTING ON IT Dr.Divyajyothi Bpharmacy and Pharmd Nervous system Central Nervous System (CNS) Brain spinal cord sensory neurons Parasympathetic Nervous system (PNS) (Cholinergic) Peripheral Nervous System (PNS) Autonomic Nervous System (Involuntary) Motor neurons Somatic Nervous System (Voluntary) sensory neurons Sympathetic neurvous system (SNS) (Adrenergic) Enteric Nervous System (ENS) Motor neurons Parasympathetic (Cholinergic )Nervous System : Cholinergic receptors are mainly two types : 1.Nicotinic receptors (N) 2. Muscarinic receptors(M) Nicotinic receptors (N) Muscle type (Nn) Ganglionic type (Nn) CNS type Muscarinic receptors(M) v M1 /Neural type M3 / smooth Muscle type M2 / Cardiac type M5 M4 Parasympathomimetics/cholinomimetics : • These are known as cholinergic or Muscarinic agonists.These drugs mimic the action of endogenous neurotransmitor,Ach by directly acting on the cholinergic receptors and releasing Ach. Parasympathomimetics : 1. Choline esters eg: 2. Plant Alkaloids eg : Acetylcholine Methacholine Carbachol Bethanechol Pilocarpine Muscarine Arecoline Nicotine 3. Anticholinesterases/Ach esterase Inhibitors (i) Reversible Ach EI Quaternary compounds : eg : Physostigmine Neostigmine Donepezil Pyridostigmine Edrophonium Galanotamine Acridine : eg : Tacrine (ii) Irrversible AchEI : Organophosphates : eg : Dyflos Parathion Ecothiophate Diazinon Carbonates : eg : Carbaryl Parasympatholytics/Antichol ...
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