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PHARMACOLOGY Dr. Divyajyothi Bpharmacy and Pharmd General Pharmacology : • The term Pharmacology is derived from Greek word “Pharmacon” which means “drug” logos means science. • Science that deals with drugs. Branches of Pharmacology : pharmacotherapeutics pharmacotherapy clinical pharmacy pharmacodynamics PHARMACOLOGY Biopharmaceutics Pharmacokinetics (ADME) Toxicology Medicinal chemistry Sources of drug : ➢Natural source ➢Animal source ➢Mineral source ➢Synthetic Route Of Administration Enternal Route (external) Sublingual and Buccal route Oral Rectal route Topical route Parentral route Intravenous Intramuscular Intraperitoneal Intrathecal/Intraspinal Intramedullary Intra-arterial Intra- articular subcutaneous Inhalation Ocular Transcutaneous Vagina and Uretral route Transdermal patches Injuction MECHANISM OF DRUG ACTION Receptor mediated Mechanism • • • • Channel -linked (Inotropic) receptors G-protein couplereceptor Kinase-linked receptor Receptor that regulate gene Non- Receptor mediated Mechanism • Chemical mechanism • Enzymatic mechanism • Physical mechanism Factors effecting Drug Action : ➢ Age,Body weight,Surface Area ➢ Sex ➢ Pregnancy and Lactation ➢ Genetic factors ➢ Physioligical stat or emotional (psychological) ➢ Food ➢ Route of administration ➢ Dosage form ➢ Metabolic distribution ➢ Accumlation ➢ Combined effects of drug AGONISTS : These drugs posses high affinity and intr ...
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