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Central dogma lecture notes

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26/05/2021 CENTRAL DOGMA This Photo by Unknown Author is licensed under CC BY-SA-NC Nucleic Acids 1 26/05/2021 Nucleotide Monomers Nucleotide Monomers 2 26/05/2021 Nucleotide Polymers The DNA Double Helix 3 26/05/2021 The DNA Double Helix The DNA Double Helix 5 end O OH P –O Hydrogen bond 3 end OH O O O O CH2 O O H2C O –O P G O C O CH2 O O O O C O G O O– P O O P CH2 O O H2C O A OH 3 end O T CH2 O O (b) Partial chemical structure O– P O O Figure 16.7b O– P O O O H2C –O T O P –O A O– P O 5 end 4 26/05/2021 The Central Dogma Replication A T A T A C G C G C T G T A T A T A A T A T A T G C G C G C A T A T A T C G C G C G T A A T A T A T A T A T C G C G C G (a) The parent molecule has two complementary strands of DNA. Each base is paired by hydrogen bonding with its specific partner, A with T and G with C. (b) The first step in replication is separation of the two DNA strands. (c) Each parental strand now serves as a template that determines the order of nucleotides along a new, complementary strand. (d) The nucleotides are connected to form the sugar-phosphate backbones of the new strands. Each “daughter” DNA molecule consists of one parental strand and one new strand. 5 26/05/2021 Replication Parent cell First replication Second replication Conservative model. The two parental strands reassociate after ac ...
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