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BUITEMS Quality & Excellence in Education J. App. Em. Sc Vol 4, Issue 2, December 2013 Development of Resistance Mechanism in Mosquitoes: Cytochrome P450, the Ultimate Detoxifier Arif Malik1, Khalid Mahmud Khan2, Muhammad Asif,3 Hafiz Muhammad Arsalan1, Sara Zahid1, Abdul Manan1, Hafiza Shamaila Murawat1, Mahmood Husain Qazi4, Mahmood Rasool5 1Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, 2Fatima Jinnah Medical College, Sir Gangaram Hospital Lahore, 3Office of Research Innovation and Commercialization, Balochistan University of Information Technology Engineering and Management Sciences, Quetta, 4Center for Research in Molecular Medicine (CRiMM), The University of Lahore, 5Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia. Abstract The development of resistance in different species of mosquitoes increases day by day. Malaria, yellow fever, dengue and many other diseases spread by the mosquitoes. According to the WHO report, it is estimated that about 247 million individuals are infected by malaria every year. Biochemical, physiological and behavioral resistance exists in mosquitoes. Glutathione-Stransferase (GST), carboxylesterase and Cytochrome P450 are enzymes families playing role in the metabolic resistance. These enzymes play key role in pyrethroid, carbamate and xenobiotic detoxification and metabolism. Several cytochrome P450 enzymes present in mosquitoes cause resistance. ...
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