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Final for review Factors Predisposing to Cleft Lip and Cleft Palate in Children

Final for review Factors Predisposing to Cleft Lip and Cleft Palate in Children

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Factors Predisposing to Cleft Lip and Cleft Palate in Childern in Tertiary Care Hospital Introduction The greatest asset of any country is the new generation of healthy, intelligent and wise children. This asset is made inefficient, if the children are born with congenital malformations. 1 A significant component of human birth defects are comprised of craniofacial anomalies and the second most common entity in this group are Oral clefts. 2 Clefts of the lip and palate represent a heterogeneous group of disorders affecting the lips and oral cavity and are generally divided into two groups, isolated cleft palate and cleft lip with or without cleft palate. Orofacial clefts may involve the lip, the roof of the mouth (hard palate), or the soft tissue in the back of the mouth (soft palate). Oral, facial, and craniofacial deformity occurs when there is involvement of these structures.3 These defects arise in about 1.7 per 1000 live-born babies, with ethnic and geographic variation.4 The incidence varies by race, sex and geographic location. Asians are at higher risk than whites or blacks. 1 A research from Pakistan showed that out of total 61,156 births, 117 children were born with oral clefts with the incidence to be 1.91/1000 live births. 5 A review article revealed that the prevalence of cleft lip and cleft palate was from 0.78 to 2.14 in Iranian children.1 Isolated CL or CP was present in 57.5% and there was syndromic association in 2.7%.2,9 A much higher percentage of malfo ...
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