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SUMMARY Relationship between cerebellar structure and emotional

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This study (Li-Yan, et al., 2017) compares the volume density and volume of the cerebellar
gray matter in patients suffering from major depressive disorder with those in disease free
controls and also explores the link amongst these cerebellar parameters and quantification of
the emotional memory and clinical severity. The study employs Voxel-based morphometry
VBM and Individual Brain Atlases using Statistical Parametric Mapping techniques to
measure the gray matter density/volume present in the cerebellum in the patients with major
depressive disorder and the controls. Some indicators of emotional memory performance
were quantified which include the hit rate, rate of false alarm, precision and emotional
memory enhancement values. Beck Depression Inventory scores were employed to quantify
the severity of depression in patients. Results of the study show that in depressed patients, the
gray matter density was lowered in 3 regions of cerebellar cortex and elevated in 3 regions of
the cerebellar cortex. The gray matter volumes in 8 regions of cerebellar cortex were quite
smaller in the depressed patients compared to the healthy controls. The study concludes that
in the patients having major depressive disorder, human emotional memory and magnitude of
symptoms of depression are linked with anatomical changes in posterior and anterior gray
matter area in the cerebellum.
This study is quite helpful in understanding the underlying anatomical and physiological
factors which are associated with the development of diseases like Major Depressive Disorder.
This study also tells us about the link of emotional memory with depression and with the
changes in the brain that are responsible for its deterioration.
References
L.-Y. X., F.-C. X., C. L., Y.-F. J., J.-M. W., Y. W., et al. (2017). Relationship between cerebellar structure
and emotional. Brain and Behavior.

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This study (Li-Yan, et al., 2017) compares the volume density and volume of the cerebellar gray matter in patients suffering from major depressive disorder with those in disease free controls and also explores the link amongst these cerebellar parameters and quantification of the emotional memory an ...
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