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Intro Plag Check

Intro Plag Check

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Childbearing is one of the fundamentally imperative physiological

properties of life, especially in the case of human beings. The locus of

technical knowledge in the fields of gynecology, obstetrics and

paediatrics is to ensure the birth of healthy and defect free offspring. The

largest asset of a country is its new generation of healthful, diligent,

brilliant, and mindful youngsters. Congenital abnormalities appearing in

the children is a major reason resulting in the nullification of this precious

asset rendering it inefficient and leading to great losses in the human

capital. Cleft lip and palate with a measured worldwide incidence of 1 in

every 700 live births, is one of these malformations

Cleft lip and palate are congenital abnormalities which affect three in

thousand live births

. Cleft lip and palate are among the commonest

birth anomalies due to the abnormal facial growth in the foetal life

. Cleft

lip which can co-exist with or can be in the absence of cleft palate (CP),

are amongst the commonest malformations in the in infants. Asians are

at higher risk for or facial clefts, followed by Caucasians and African

Americans

4, 5

. In Iran, its prevalence is varied from 0.93 to 1.03 per

1,000 births

As per the statistics, in every seven hundred live births occurring in

United States of America, one new-born suffers from facial clefts.

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Therefore, every year five thousand new-borns suffer from cleft lip and

palate in United States of America meaning thereby that in each 2

minutes a new-born with cleft lip and palate takes their very first breath

Cleft lip alone or a cleft lip concomitant with a cleft palate are classified

as cranio-facial birth abnormalities and mostly happens 1 in 1000 births

. Sufferers of cleft palate mostly require several forms of surgery and

additional complicated surgical interventions

. The cleft in its nature can

be uni-lateral, bi-lateral, complete or partially complete. The

predisposing factors of cleft lip and cleft palate may be ascertained by

genome of the parents and can be determined from the phenotyping of

both the parents

Albeit such abnormalities are mostly due to genetic influences, an

estimated 20% of such are generated as a result of environmental

issues and teratogens in the embryo development which are mostly

responsive to prevention. Among these factors are cousin marriages,

usage of medication, weather fluctuations, alcohol use, active and

passive smoking, obesity in mother, and hereditary influencers like race

and ethnicity etc.

1, 7, 11, 12

According to various complications of the abnormality, it is likely that the

disease aetiology is sum of hereditary and environmental influences

Various studies have demonstrated that seventy per cent of cleft lip and

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Childbearing is one of the fundamentally imperative physiological properties of life, especially in the case of human beings. The locus of technical knowledge in the fields of gynecology, obstetrics and paediatrics is to ensure the birth of healthy and defect free offspring. The largest asset of a country is its new generation of healthful, diligent, brilliant, and mindful youngsters. Congenital abnormalities appearing in the children is a major reason resulting in the nullification of this precious asset rendering it inefficient and leading to great losses in the human capital. Cleft lip and palate with a measured worldwide incidence of 1 in every 700 live births, is one of these malformations 1. Cleft lip and palate are congenital abnormalities which affect three in thousand live births 2. Cleft lip and palate are among the commonest birth anomalies due to the abnormal facial growth in the foetal life 3. Cleft lip which can co-exist with or can be in the absence of cleft palate (CP), are amongst the commonest malformations in the in infants. Asians are at higher risk for or facial clefts, followed by Caucasians and African Americans 4, 5. In Iran, its prevalence is varied from 0 ...
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