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Intro Plag Check

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Childbearing is one of the fundamentally imperative physiological
properties of life, especially in the case of human beings. The locus of
technical knowledge in the fields of gynecology, obstetrics and
paediatrics is to ensure the birth of healthy and defect free offspring. The
largest asset of a country is its new generation of healthful, diligent,
brilliant, and mindful youngsters. Congenital abnormalities appearing in
the children is a major reason resulting in the nullification of this precious
asset rendering it inefficient and leading to great losses in the human
capital. Cleft lip and palate with a measured worldwide incidence of 1 in
every 700 live births, is one of these malformations
1
.
Cleft lip and palate are congenital abnormalities which affect three in
thousand live births
2
. Cleft lip and palate are among the commonest
birth anomalies due to the abnormal facial growth in the foetal life
3
. Cleft
lip which can co-exist with or can be in the absence of cleft palate (CP),
are amongst the commonest malformations in the in infants. Asians are
at higher risk for or facial clefts, followed by Caucasians and African
Americans
4, 5
. In Iran, its prevalence is varied from 0.93 to 1.03 per
1,000 births
6
.
As per the statistics, in every seven hundred live births occurring in
United States of America, one new-born suffers from facial clefts.

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Therefore, every year five thousand new-borns suffer from cleft lip and
palate in United States of America meaning thereby that in each 2
minutes a new-born with cleft lip and palate takes their very first breath
7
.
Cleft lip alone or a cleft lip concomitant with a cleft palate are classified
as cranio-facial birth abnormalities and mostly happens 1 in 1000 births
8
. Sufferers of cleft palate mostly require several forms of surgery and
additional complicated surgical interventions
9
. The cleft in its nature can
be uni-lateral, bi-lateral, complete or partially complete. The
predisposing factors of cleft lip and cleft palate may be ascertained by
genome of the parents and can be determined from the phenotyping of
both the parents
10
.
Albeit such abnormalities are mostly due to genetic influences, an
estimated 20% of such are generated as a result of environmental
issues and teratogens in the embryo development which are mostly
responsive to prevention. Among these factors are cousin marriages,
usage of medication, weather fluctuations, alcohol use, active and
passive smoking, obesity in mother, and hereditary influencers like race
and ethnicity etc.
1, 7, 11, 12
.
According to various complications of the abnormality, it is likely that the
disease aetiology is sum of hereditary and environmental influences
13
.
Various studies have demonstrated that seventy per cent of cleft lip and

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Childbearing is one of the fundamentally imperative physiological properties of life, especially in the case of human beings. The locus of technical knowledge in the fields of gynecology, obstetrics and paediatrics is to ensure the birth of healthy and defect free offspring. The largest asset of a country is its new generation of healthful, diligent, brilliant, and mindful youngsters. Congenital abnormalities appearing in the children is a major reason resulting in the nullification of this precious asset rendering it inefficient and leading to great losses in the human capital. Cleft lip and palate with a measured worldwide incidence of 1 in every 700 live births, is one of these malformations 1. Cleft lip and palate are congenital abnormalities which affect three in thousand live births 2. Cleft lip and palate are among the commonest birth anomalies due to the abnormal facial growth in the foetal life 3. Cleft lip which can co-exist with or can be in the absence of cleft palate (CP), are amongst the commonest malformations in the in infants. Asians are at higher risk for or facial clefts, followed by Caucasians and African Americans 4, 5. In Iran, its prevalence is varied from 0 ...
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