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N515 Module 6 Part 2 Respiratory Medications S 2021

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Respiratory Medications Add-On Agents  Add-On Therapy o Other agents that have shown benefit in the treatment of either asthma or COPD but are not first-line agents I.           Leukotriene Modifiers (LTRA) Leukotrienes contribute to inflammation Drugs that modify or antagonize leukotrienes will decrease inflammation, edema, and mucus secretion Used for asthma, COPD, and allergies Improve lung function Reduce the use of beta-2 agonists Decrease the number of asthma exacerbations Reduce exercise-induced bronchoconstriction Zafirlukast (Accolate) Zileutin (Zyflo) Montelukast (Singulair)  Zafirlukast o Twice daily prophylaxis and chronic treatment of asthma in patients > 5 years of age o Drug interactions are common o Reports of fatal hepatic failure have been noted  Should monitor hepatic function  Zileutin o o Twice daily prophylaxis and chronic treatment of asthma in patients > 12 years of age Drug interactions are common with zileutin  Montelukast o Once daily prophylaxis and chronic treatment of asthma in patients 12 months of age and older o Also used as a first-line agent for allergic rhinitis o Chewable and regular tablets o Side effects of montelukast – pretty well-tolerated by most patients  CNS – Headache, dizziness  GI  Neuropsychiatric events with LTRAs has been in place for awhile, but has now been enhanced to a black box warning o Caution about use in patients with mild symptoms Adverse events p ...
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