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N515 Module 5 Part 6 Antiplatelet Agents S 2021

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Antiplatelet Agents Antiplatelet Therapy  Platelet activation, which occurs in response to vessel injury, produces coronary occlusion either by formation of a platelet plug through release of vasoactive compounds from the platelet  Antiplatelet drugs inhibit platelet aggregation → decreases production of coronary occlusions o Inhibits formation of cyclo-oxygenase o The P2Y12 receptor also plays a key role in platelet aggregation o Direct-acting P2Y12 platelet inhibitors block adenosine diphosphate (ADP) –induced platelet activation and aggregation      Aspirin Dipyridamole (Persantine) Dipyridamole/ Aspirin (Aggrenox) P2Y12 Inhibitors o Clopidogrel (Plavix) o Prasugrel (Effient) o Ticagrelor (Brilinta) o Cangrelor (Kengreal) PAR-1 Antagonist o Vorapaxar (Zontivity) Aspirin          Works by inhibiting cyclo-oxygenase Indications: o Acute MI o Secondary prevention of MI o TIA or stroke o Chronic stable or unstable angina o Revascularization procedures  Part of dual therapy with a P2Y12 inhibitor  Depending on other co-morbid conditions, triple therapy of aspirin, anti-platelet, and anticoagulant may be required o Primary prevention of ASCVD in certain populations Adverse reactions: o GI effects (use of enteric-coated) o Bleeding Allergy potential o If a patient is truly aspirin allergic, may consider a desensitization protocol Chronic NSAID use can compromise anti-platelet effects No specific antidote o Platelet ...
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