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6 Blood Cells Part II WBCs 2

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Structure & Function of WBC’s THE CELLULAR COMPONENT OF THE CARDIOVASCULAR SYSTEM 1 Leukocytes Leukocytes (white blood cells or WBCs) are nucleated cells and do not contain hemoglobin. Two principal types are granular (neutrophils, eosinophils, basophils) and agranular (lymphocytes and monocytes) ◦ Granular leukocytes include eosinophils, basophils, and neutrophils based on the straining of the granules. ◦ Agranular leukocytes do not have cytoplasmic granules and include the lymphocytes and monocytes, which differentiate into macrophages (fixed and wandering). PRINCIPLES OF HUMAN ANATOMY AND PHYSIOLOGY, 11E 2 Surface Markers Leukocytes have surface proteins, as do erythrocytes. Major Histocompatibility Antigens (MHC), are unique for each person (except for identical siblings) Genes that code for cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility. PRINCIPLES OF HUMAN ANATOMY AND PHYSIOLOGY, 11E 3 Function of WBCs: Granulocytes Different WBCs combat inflammation and infection in different ways: ◦ Neutrophils (which develop from monocytes) do so through phagocytosis. ◦ Eosinophils combat the effects of histamine in allergic reactions, phagocytize antigen-antibody complexes, and combat parasitic worms. ◦ Basophils develop into mast cells that liberate histamine, and serotonin in allergic reactions that intensify the inflammatory response. PRINCIPLES OF H ...
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