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Osteoarthritis Case study

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Running head: OSTEOARTHRITIS 1
Osteoarthritis
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OSTEOARTHRITIS 2
Case Study: Osteoarthritis
Osteoarthritis is a type of degenerative bone disease affecting more than 30 million
people in the USA that is responsible for chronic disability, longstanding dependence, and
significant health burden. It is commonly a disease of the elderly and is heralded by the
progressive breakdown of hyaline cartilage in the hip, knee and vertebral joints, which leads to
chronic pain and dysmobility (Glyn-Jones et al., 2015). Management options range from pain
control (which is the mainstay) to reducing inflammation and surgical alternatives such as
arthroplasties (Glyn-Jones et al., 2015). Symptomatic osteoarthritis is a major socioeconomic
concern.
Drug Interaction
Diclofenac is a non-steroidal anti-inflammatory drug that acts by non-selectively
inhibiting the cyclooxygenase enzyme, while coumadin is an anticoagulant that derives its
activity from the reversible vitamin K inhibition (Goswami, Ghoshal, Hazra, & Biswas, 2018).
Effectively, the use of these two categories of medications is discouraged due to the possibility
of bleeding since the COX inhibition too leads to depressed platelet function and prolonged
bleeding time, thereby leading to disruption of coagulation.
Viable Alternatives
The osteoarthritis pain is usually localized to the affected joints and, thus, is not systemic.
In this regard, local therapies can be very effective. An example is the intra-articular
corticosteroid injection, commonly known as triamcinolone. Tindall, Sedrak, and Boltri (2014)
posit that steroid injections into the knee result in significant pain reduction from as early as 3
days after injection and lasting for as much as 6 weeks. This treatment is particularly important
since the patient minimizes hospital trips and concentrates on other non-pharmacologic measures

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Running head: OSTEOARTHRITIS 1 Osteoarthritis Name Surname University OSTEOARTHRITIS 2 Case Study: Osteoarthritis Osteoarthritis is a type of degenerative bone disease affecting more than 30 million people in the USA that is responsible for chronic disability, longstanding dependence, and significant health burden. It is commonly a disease of the elderly and is heralded by the progressive breakdown of hyaline cartilage in the hip, knee and vertebral joints, which leads to chronic pain and dysmobility (Glyn-Jones et al., 2015). Management options range from pain control (which is the mainstay) to reducing inflammation and surgical alternatives such as arthroplasties (Glyn-Jones et al., 2015). Symptomatic osteoarthritis is a major socioeconomic concern. Drug Interaction Diclofenac is a non-steroidal anti-inflammatory drug that acts by non-selectively inhibiting the cyclooxygenase enzyme, while coumadin is an anticoagulant that derives its activity from the reversible vitamin K inhibition (Goswami, Ghoshal, Hazra, & Biswas, 2018). Effectively, the use of these two categories of medications is discouraged due to the possibility of bleeding since the COX inhibition too leads to depressed platelet function and prolonged bleeding time, thereby leading to disruption of coagulation. Viable Alternatives The osteoarthritis pain is usually localized to the affected joints and, thus, is not systemic. In this regard, local therapies can be very effective. An example is the intra-arti ...
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