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A growth rate composition formula for the growth of e coli on co utilized carbon substrates

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Report A growth-rate composition formula for the growth of E. coli on co-utilized carbon substrates Rutger Hermsen1,2,‡, Hiroyuki Okano1,‡, Conghui You1,†,‡, Nicole Werner1 & Terence Hwa1,* Abstract When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates are co-utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates. Keywords bacterial growth; catabolite repression; metabolic coordination; mixed carbon-substrate growth Subject Categories Quantitative Biology & Dynamical Systems; Metabolism DOI 10.15252/msb.20145537 | Received 1 July 2014 | Revised 27 February 2015 | Accepted 27 February 2015 Mol Syst Biol. (2015) 11: 801 Introduction Bacterial cultures grown in minimal media supplemented with two carbon substrates (i.e., mixed-substrate media) can exhibit two types of behavior: In some cases, the substrates are consumed sequentially—which under the right conditions results in diauxic growth (Monod, 1942, 1947)—whereas in other cases, they are consumed simultaneously (Monod, 1942). Sequential utilization and diauxie are commonly attributed (Müller-Hill, 1996; Deutscher e ...
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