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Cause of The Periorbital Edema Discussion

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Health & Medical

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The differential diagnosis for the cause of the periorbital edema can become difficult. Specially
if the patient is over 65 years of age. Geriatric patients can have co-morbidities than can impact
the eye. The usual causes are trauma and infectious causes that can be bacterial or fungal and
generate orbital cellulitis. There are other differentials like sarcoidosis, Wegener’s disease.
Another consideration as a cuase is tumors like lymphoma, lymphangioma, lacrimal gland
tumors and cavernous hemangioma and angiosarcoma (Chow & Ang, 2021). There is also a
possibility of a carotid cavernous fistula, cavernous sinus thrombosis.
Considering that many geriatric patients take several medications the fact that the periorbital
edema be a consequence of the drug needs to be evaluated.
According to Yu & Guan, 2020). the most recent generation of bisphosphonates, contain a
nitrogen group that has been reported to activate gamma delta (γδ) T-cells and lead to phase
reaction. It has been suggested that this mechanism in amino-bisphosphonates can cause ocular
inflammation, although rarely. In recent years, there have been multiple reports of inflammatory
ocular side effects from amino- bisphosphonates”.
Reference
Chow, K. Y., Ko, S., & Ang, Q. (2021). Rapidly Progressive Periorbital Oedema: A Case of
Cutaneous Angiosarcoma. Case reports in oncology, 14(1), 531537.
https://doi.org/10.1159/000514304
Yu, J., & Guan, J. (2020). Bisphosphonate-Induced Acute Orbital Inflammation in a Patient With
Underlying Thyroid Ophthalmopathy. Cureus, 12(12), e12024.
https://doi.org/10.7759/cureus.12024

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The differential diagnosis for the cause of the periorbital edema can become difficult. Specially if the patient is over 65 years of age. Geriatric patients can have co-morbidities than can impact the eye. The usual causes are trauma and infectious causes that can be bacterial or fungal and generate ...
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Very useful material for studying!

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