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Infective Endocarditis Inflammatory Process Presentation

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Infective endocarditis By Ogunmola EniolaDEN/15/0190 Outline 1. 2. 3. 4. 5. 6. Introduction Epidemiology Pathogenesis Predisposing factors Clinical symptoms Diagnosis 1. 2. 3. Duke criteria Blood cultures Echocardiography 7. Treatment basics 8. Complications 9. Prophylaxis 10.Conclusion Introduction • Infective endocarditis – inflammatory process on-going inside endocardiu m – due to infection after endothelium damage – most often involving aortic and mitral valves • Associated with febrile illness and persistent bacte remia • Most cases are bacterial, fungal,rickettsia, chlamy dia Introduction ctnd. Acording to localisation • Left sided IE – Native valve IE (NVE) – Prosthetic valve IE(PVE) • Early < 1 year after surgery • Late >1 year after surgery • Right sided IE • Device- related IE (ICD) Introduction ctnd. Acording to the mode of acquisition • Health-care associated IE – Nosocomial – Non-nosocomial • Community acquired IE • Intravenous drug abuse-associated IE According to occurrence of infection • Active IE • Recurrence – Relpse – Reinfection Epidemiology • • • • 3-10/100 000/year Maximum at the age of 70-80 More common in women Staphylococcus aureus is the most common pa thogen • Streptococcal IE is still the most common in developing countries Pathogenesis • Underlying valvular or non valvular structural abnormality • Blood flow turbulence • Endothelial disruption • Platelet and Fibrin d ...
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