Role of E-Cadherin in Cancer

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The CDH1 (human epithelial (E-cadherin) resembles the chromosome 16q22.1.1 and was first isolated in full length using the recombinant lambda phage, P1 phage as well as cosmid phage clones. The gene cloned has 16 exons and its span is of close to 100 kb. The range of the exons is between 115 and 2245 bp. On subjection to further analysis, the gene was discovered to contain 15 introns that ranged from 120 bp (intron four) upto 65 kb (intron two).

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Surname 1Last Name:Course:Name of professor:Date of Submission:Role of E-Cadherin in CancerGene/ Protein Structure of CadherinThe CDH1 (human epithelial (E-cadherin) resembles the chromosome 16q22.1.1 and wasfirst isolated in full length using the recombinant lambda phage, P1 phage as well as cosmid phageclones. The gene cloned has 16 exons and its span is of close to 100 kb. The range of the exons isbetween 115 and 2245 bp. On subjection to further analysis, the gene was discovered to contain15 introns that ranged from 120 bp (intron four) upto 65 kb (intron two). The intro-exon(interphases) boundaries are conserved highly with respect to the other classical cadherins. Later,intron 1 a 5 with a high density CpG island was also discovered and is thought to play a key rolein regulation of transcription process. The island extends over a region covering exon 1 all the wayto the second exon in the E-cadherin gene of human. Other exons do not possess such features forinstance the biggest exon 16 that has 2245 bp (Berx G).Figure 1: E-Cadherin gene and protein structureSurname 2Note that, the figure above shows an illustration of the genomic organization found in thehuman E-Cadherin gene. The positions of the exons are shown in the colored boxes and each basepair number for each exon. The introns are indicated as the connection lines. The region that iscovered by exon number 1 to exon number 2 is a series of approximately 1500 bp. This is the highdensi
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