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Comparative study between clomiphene and Letrozole for ovulation induction in patients with polycyst

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Comparative study between clomiphene and
Letrozole for ovulation induction in patients with polycystic
ovarian syndrome
[Writers name]
SUPERVISOR
[Supervisors name]
ZIAUDDIN UNIVERSITY
Synopsis

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INTRODUCTION
Polycystic ovary syndrome is a heterogeneous endocrine dysfunction that affects about ¼
of women worldwide. This is majorly due to excessive androgen secretion or activity in the body
and an enormous number of women may also have abnormal insulin activity. Various systems of
the body get disturbed due to polycystic ovarian syndrome resulting in several complications
including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome.
Women with this disorder have an established increased risk of developing type 2 diabetes i.e.;
non-insulin dependent and a still debated increased risk of cardiovascular disorder.
Letrozole induction of ovulation in women with clomiphene citrate–resistant polycystic
ovary syndrome may not depend on the period of infertility, the body mass index, or the
luteinizing hormone/follicle-stimulating hormone ratio.
Generally there was no significant difference seen in responders and non-responders of
letrozole in age, period of infertility, body mass index, and LH, FSH, or LH/FSH ratio.
This syndrome is common in women of reproductive age. Infrequent or prolonged
menstrual periods, excess hair growth, acne and obesity can all occur at once or individually in
women with polycystic ovary syndrome. Infrequent or absent menstruation may indicate the
presence of this condition. In women, weight gain and difficulty in conceiving is the first sign of
this syndrome.
Clomiphene is a standard drug for the ovulation induction and is still considered as the
first line therapy treatment for the PCOS. However clomiphene has certain disadvantages as
well. It is associated with inconsistency in ovulation (60-85%) and pregnancy rate (10-20%).

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INTRODUCTIONPolycystic ovary syndrome is a heterogeneous endocrine dysfunction that affects about of women worldwide. This is majorly due to excessive androgen secretion or activity in the body and an enormous number of women may also have abnormal insulin activity. Various systems of the body get disturbed due to polycystic ovarian syndrome resulting in several complications including menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. Women with this disorder have an established increased risk of developing type 2 diabetes i.e.; non-insulin dependent and a still debated increased risk of cardiovascular disorder.Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio.Generally there was no significant difference seen in responders and non-responders of letrozole in age, period of infertility, body mass index, and LH, FSH, or LH/FSH ratio.This syndrome is common in women of reproductive age. Infrequent or prolonged menstrual periods, excess hair growth, acne and obesity can all occur at once or individually in women with polycystic ovary syndrome. Infrequent or absent menstruation may indicate the presence of this condition. In women, weight gain and difficulty in conceiving is the first sign of this syndrome.Clomiphene is a standard drug f ...
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