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Chemistry Paper Edited

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Running head: SYNTHESIZING TARGET MOLECULE Synthesizing Target Molecule Name Institution Affiliation SYNTHESIZING TARGET MOLECULE 2 Introduction In this paper, the aim is to synthesize a new molecule from a molecule of Ni-ARD enzyme. The target molecule in this paper is similar slightly different from the original molecule. A modification of the original molecule of the enzyme nickel acireductone dioxygenase (Ni-ARD), was done by replacing the H2O group with an acetate group. Nickel acireductone dioxygenase is the only known dioxygenase existing naturally (Hausinger, 1993). The target molecule, which is the molecule of study in this case, differs from the original molecule in that the acetate group added replacing of the H2O group affects the way the Ni-ARD works as a catalyst. Literature Background Nickel acireductone dioxygenase, an enzyme, is the nickel-bound form of ARD enzyme, which catalyzes off-pathway reactions leading in formate, 5-(thiomethyl) propionate, and carbon monoxide (Ragsdale, 2009). The Ni element, a key element of the original and the target molecules, is crucial to the thriving of various life forms (Chen & Costa, 2009). However, excess levels of Ni are highly carcinogenic and toxic according to a study by Chen and Costa (2009). As such, living cells have structured mechanisms to sense the Ni concentration and then maintain homeostatic control of the metal ion according to Hausinger (1993). Nickel ion-binding sites in Ni-dependent enzymes like Nicke ...
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