Select one of the case studies below for your assignment. In your discussion, be sure to integrate your knowledge of advanced pathophysiology across the lifespan with the clinical implications for the advanced practice nurseCase Study Assignment Requirements:Make sure all of the topics in the case study have been addressed.Cite at least three references in your case study paper; this may include peer-reviewed journal articles, textbooks, or evidence-based practice websites to support the content.All reference sources must be within 5 years.Do not use sources such as Wikipedia or UpToDate as a reference.Assignments must have at least four full pages of analytic content, double-spaced (the cover and reference pages do not count in the page count, but must be included with the assignment), and follow APA 7th edition format.Assignment: Six Case Studies to Choose From (Taken from Units 1 & 2 Readings)Case Study 1: Cellular Adaptation, Injury, and DeathMaria is a sedentary, 68-year-old woman who is overweight. She complains that her hands and feet are always cold, and she tires quickly when cleaning the house. At her most recent visit to her doctor, her blood pressure was 184/98 mm Hg. She has edema around her ankles and legs, and her physician is concerned about an echocardiogram that indicates Maria has an enlarged heart.Identify two reasons why Maria will have tissue ischemia. How might this lead to hypoxia?What are the two early and reversible changes that occur to tissue cells when they are hypoxic?What specific type of cellular adaptation has taken place in Maria’s enlarged heart? What made you come to this conclusion?Case Study 2: Genetic Control of Cell Function and InheritanceMarsha and Clement are both carriers of sickle cell anemia, a disease that is autosomal recessive. Their first child, Amelia, does not have the disease. Marsha and Clement are planning another pregnancy, but they are concerned about their second child having the condition. Clement’s father died from complications of sickle cell disease shortly before Amelia was born.Draw a Punnett square to determine the likelihood of Marsha and Clement having a baby with sickle cell anemia. What is the chance the baby will be a carrier of the disease, just like the parents?Marsha suggested to the nurse at the local family planning clinic that if the baby were a boy, he might have a higher risk of developing the disease, just like his grandfather. If you were this nurse, how would you respond?When Amelia, who does not have sickle cell anemia, grows up and marries someone who does have the disease, how likely will her children have the disease?Case Study 3: Genetic and Congenital DisordersFelicity is a very busy 29-year-old woman in a professional career. She has diabetes mellitus and is also pregnant for the first time. Because of her busy schedule, it was over 3 weeks after missing her menstrual cycle when she visited her family doctor to have the pregnancy confirmed. Felicity became very concerned when her physician asked if she had been taking folic acid. It was all Felicity could do to remember to manage her insulin levels, and taking folic acid supplements was something she had not even considered. Her doctor told her to take 600 μg of folic acid daily and advised Felicity to return later for maternal serum marker testing.Explain the potential teratogenic effect of folic acid deficiency on the developing fetus. What other risk factor is noteworthy in Felicity’s case?What is the benefit of maternal serum marker testing? What other test would be particularly useful to monitor the development of Felicity’s baby in this situation?When is the fetus most vulnerable to the effects of teratogens and why?Case Study 4: Inflammation, Tissue Repair, and Wound HealingCarlton, a 6-year-old boy, was playing on a sandy beach with his mother. He began to run along the shoreline when he stepped on the sharp edge of a shell, giving himself a deep cut on his foot. His mother washed his foot in the lake and put on his running shoe to take him home. One day later, Carlton’s foot looked worse. The gash was red and painful. The foot was warm to touch and appeared swollen. Carlton’s mom put some gauze over the wound and prepared to take him to the local community health clinic.What is the physiologic mechanism causing the wound to become red, hot, swollen, and painful? How is this different from the inflammatory response that might occur in an internal organ?What are the immunologic events that are happening at the local level during Carlton’s acute inflammatory response?Nutrition plays an important factor in wound healing. What stages of wound healing would be affected by a deficiency in vitamins A and C?Case Study 5: Innate and Adaptive ImmunityMelissa is a 15-year-old high school student. Over the last week, she had been feeling tired and found it difficult to stay awake in class. By the time the weekend had arrived, she developed a sore throat that made it difficult to eat and even drink. Melissa was too tired to get out of bed, and she said her head ached. On Monday morning, her mother took her to her doctor. Upon completing the physical exam, he told Melissa that the lymph nodes were enlarged in her neck, and she had a fever. He ordered blood tests and told Melissa he thought she had mononucleosis, a viral infection requiring much bed rest.Innate and adaptive immune defenses work collectively in destroying invasive microorganisms. What is the interaction between macrophages and T lymphocytes during the presentation of antigen?Melissa’s illness is caused by a virus. Where are type I interferons produced, and why are they important in combating viral infections?Humoral immunity involves the activation of B lymphocytes and production of antibodies. What are the general mechanisms of action that make antibodies a key component of an immune response?Before finalizing your work, it is important to:Review Case Study Assignment Requirements (described above) and the Case Study Assignment Grading Rubric (under the Course Resources), to ensure you have completed all required elements of the assignment.Make sure to review your chosen case study carefully to make sure you have effectively answered all questions asked.Utilize spelling and grammar checks to minimize errors.Follow the conventions of Standard English (correct grammar, punctuation, etc.).Make sure your assignment is original, insightful, and utilizes your logic and critical thinking skills; that your assignment is well-organized, with superior content, style, and mechanics.Utilize APA 7th edition format.Be diligent about APA formatting including paraphrasing and direct quotations, utilizing appropriate in-text citations, and referencing your sources.

Nurse-scholars have a significant obligation to their community as well. Their work must have academic and professional integrity. Their efforts are designed to add to the body of knowledge, advance the profession, and ultimately help in the care of patients. Work that lacks integrity is subject to erode quickly or worse.Fortunately, there are strategies and tools that can help ensure integrity in academic and professional work. This Assignment asks you to consider these tools and how you might apply them to your own work.In this Assignment you will continue developing your Academic Success and Professional Development Plan by appending the original document you began in the previous assignment.To Prepare:Reflect on the strategies presented in the Resources for this Module in support of academic style, integrity, and scholarly ethics.Reflect on the connection between academic and professional integrity.The Assignment:Part 3, Section 1: Writing Sample: The Connection Between Academic and Professional IntegrityUsing the Academic and Professional Success Development Template you began in Module 1 and expanded in Module 2, write a 2- to 3-paragraph analysis that includes the following:Explanation for the relationship between academic integrity and writingExplanation for the relationship between professional practices and scholarly ethicsCite at least two resources that support your arguments, being sure to use proper APA formatting.Use Grammarly and SafeAssign to improve the product.Explain how Grammarly, Safe Assign, and paraphrasing contributes to academic integrity.Part 3, Section 2: Strategies for Maintaining Integrity of WorkExpand on your thoughts from Section 1 by:identifying and describing strategies you intend to pursue to maintain integrity and ethics of your: (1) academic work as a student of the MSN program and (2) professional work as a nurse throughout your career. Include a review of resources and approaches you propose to use as a student and a professional.****Note: Add your work for this Assignment to the original document you began in the Module 1 Assignment, which was built from the Academic Success and Professional Development Plan Template.RUBRICName: NURS_6003_Module03_Week05_Assignment_RubricGrid ViewList View ExcellentGoodFairPoorPart 1: Writing Sample: The Connection Between Academic and Professional IntegrityUsing the Academic and Professional Success Development Template you began, write a 2-3 paragraph analysis that includes the following:· Explanation for the relationship between academic integrity and writing.· Explanation for the relationship between professional practices and scholarly ethics.· Cite at least 2 resources that support your arguments, being sure to use proper APA formatting.· Use Grammarly and SafeAssign to improve the product.· Explain how Grammarly, SafeAssign, and paraphrasing contributes to academic integrity.32 (32%) - 35 (35%)The response clearly and accurately describes in detail the relationship between academic integrity and writing.The response clearly and accurately describes in detail the relationship between professional practices and scholarly ethics.The response accurately cites at least two resources that fully support the arguments explained.The response clearly and accurately describes in detail how Grammarly, SafeAssign, and paraphrasing contributes to academic integrity, including sufficient evidence that Grammarly and SafeAssign were used to improve the responses provided.28 (28%) - 31 (31%)The response partially describes the relationship between academic integrity and writing.The response partially describes the relationship between professional practices and scholarly ethics.The response partially cites at least two resources that partially support the arguments explained.The response partially describes how Grammarly, SafeAssign, and paraphrasing contributes to academic integrity, including some evidence that Grammarly and SafeAssign were used to improve the responses provided.25 (25%) - 27 (27%)The response vaguely describes the relationship between academic integrity and writing.The response vaguely describesthe relationship between professional practices and scholarly ethics.The response vaguely or inaccurately cites at least two resources that vaguely support the arguments explained.The response vaguely or inaccurately describes how Grammarly, SafeAssign, and paraphrasing contributes to academic integrity, including vague evidence that Grammarly and SafeAssign were used to improve the responses provided.0 (0%) - 24 (24%)The response describing the relationship between academic integrity and writing is vague and inaccurate, or is missing.The response describing the relationship between professional practices and scholarly ethics is vague and inaccurate, or is missing.The response inaccurately cites at least two resources that inaccurately support the arguments explained, or is missing.The response vaguely and inaccurately describes how Grammarly, SafeAssign, and paraphrasing contributes to academic integrity, including no evidence that Grammarly and SafeAssign were used to improve the responses provided.Part 2: Strategies for Maintaining Integrity of WorkExpand on your thoughts from Part 1 by:· Identifying and describing strategies you intend to pursue to maintain integrity and ethics of your 1) academic work while a student of the MSN program, and 2) professional work as a nurse throughout your career. Include a review of resources and approaches you propose to use as a student and a professional.45 (45%) - 50 (50%)The response clearly identifies and accurately describes in detail strategies intended to pursue to maintain integrity and ethics of academic work while in the MSN program and in professional work as a nurse.The response clearly reviews and accurately proposes in detail resources and approaches to use as a student and professional.40 (40%) - 44 (44%)The response partially identifies and describes strategies intended to pursue to maintain integrity and ethics of academic work while in the MSN program and in professional work as a nurse.The response partially reviews and proposes resources and approaches to use as a student and professional.35 (35%) - 39 (39%)The response vaguely identifies and describes strategies intended to pursue to maintain integrity and ethics of academic work while in the MSN program and in professional work as a nurse.The response inaccurately reviews and vaguely proposes resources and approaches to use as a student and professional.0 (0%) - 34 (34%)The response vaguely and inaccurately identifies and describes strategies intended to pursue to maintain integrity and ethics of academic work while in the MSN program and in professional work as a nurse, or is missing.The response vaguely and inaccurately reviews and vaguely proposes resources and approaches to use as a student and professional, or is missing.Written Expression and Formatting - Paragraph Development and Organization:Paragraphs make clear points that support well developed ideas, flow logically, and demonstrate continuity of ideas. Sentences are carefully focused--neither long and rambling nor short and lacking substance. A clear and comprehensive purpose statement and introduction is provided which delineates all required criteria.5 (5%) - 5 (5%)Paragraphs and sentences follow writing standards for flow, continuity, and clarity.A clear and comprehensive purpose statement, introduction, and conclusion is provided which delineates all required criteria.4 (4%) - 4 (4%)Paragraphs and sentences follow writing standards for flow, continuity, and clarity 80% of the time.Purpose, introduction, and conclusion of the assignment is stated, yet is brief and not descriptive.3.5 (3.5%) - 3.5 (3.5%)Paragraphs and sentences follow writing standards for flow, continuity, and clarity 60%- 79% of the time.Purpose, introduction, and conclusion of the assignment is vague or off topic.0 (0%) - 3 (3%)Paragraphs and sentences follow writing standards for flow, continuity, and clarity < 60% of the time.No purpose statement, introduction, or conclusion was provided.Written Expression and Formatting - English writing standards:Correct grammar, mechanics, and proper punctuation5 (5%) - 5 (5%)Uses correct grammar, spelling, and punctuation with no errors.4 (4%) - 4 (4%)Contains a few (1-2) grammar, spelling, and punctuation errors.3.5 (3.5%) - 3.5 (3.5%)Contains several (3-4) grammar, spelling, and punctuation errors.0 (0%) - 3 (3%)Contains many (≥ 5) grammar, spelling, and punctuation errors that interfere with the reader’s understanding.Written Expression and Formatting - The paper follows correct APA format for title page, headings, font, spacing, margins, indentations, page numbers, running head, parenthetical/in-text citations, and reference list.5 (5%) - 5 (5%)Uses correct APA format with no errors.4 (4%) - 4 (4%)Contains a few (1-2) APA format errors.3.5 (3.5%) - 3.5 (3.5%)Contains several (3-4) APA format errors.0 (0%) - 3 (3%)Contains many (≥ 5) APA format errors.Total Points: 100