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15 stem cells

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Stem cells and tissue renewal Outline • Intestinal stem cells • Skin stem cells • Stem-cell-independent tissue renewal • Bone remodeling • Cell reprogramming • Regeneration The lining of the small intestine is continually renewed. APC mutations cause familial colorectal cancer Familial adenomatous polyposis coli Wnt signaling is required to maintain crypts Lgr5-expressing stem cells in the small intestine Lgr5-expressing stem cells in the small intestine Lgr5-expressing stem cells in the small intestine The fate of daughter cells from stem cell division The fate of daughter cells from stem cell division Lgr5-stem cell turnover follows a pattern of neutral drift dynamics Lgr5-stem cell turnover follows a pattern of neutral drift dynamics A single Lgr5-expressing cell in culture can generate an entire organized crypt-villus system A single Lgr5-expressing cell in culture can generate an entire organized crypt-villus system Patient-derived organoids allow peronalized therapy Paneth cells function as stem cell niche Intestinal stem cell niche Notch signaling controls gut cell diversification and helps maintain the stem cell state Notch inhibition leads to secretory cell hyperplasia. Skin stem cells • Epidermal stem cells • Hair follicle stem cells • Melanocyte stem cells Epidermal stem cells Clinical applications of epidermal stem cells The Hair follicle The hair follicle stem cells Name: Description: ...
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