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Fatty acid metabolism disorder is an autosomal recessive
disorder. Two unaffected parents have 6 children - 4 of
whom are affected, and 2 of whom are unaffected.
What are the chances that this couple will have a
heterozygous child?
Solution
Fatty acid metabolism is autosomal recessive disorder,
thus to express the disorder , both the alleles has express
recessive gene . As the parents have both affected and
non-affected children, the parents has to be heterozygous
dominant.
lets assume the dominant allele is A and recessive allele is
a
Aa X Aa
A
a
A
AA
unaffected
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Aa
unaffecetd
a
Aa
unaffected
aa
affected
hus there is a 50% chance that the couple will have
heterozygous genotype (Aa), which is unaffected for the
disorder.
A
a
A
AA
unaffected
Aa
unaffecetd
a
Aa
unaffected
aa
affected
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