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Course Task 2: Journal articles on the advancement in treatment of Degenerative disorders

Introduction

Degenerative disorders are diseases that affect the central nervous system and peripheral

nervous system. Depending on the site affected, the neuronal loss, gliosis or demyelination can lead to

motor deficits, behavioral disturbances and cognitive decline. This can be serious or life-threatening

disease. It depends on the type and most of them have no cure. Treatments may help improve

symptoms, relieve pain, and increase mobility. This article intends to review the advantageous role of

plants and secondary metabolites in the prevention and management of degenerative disorders.

Method

Researchers directed a PubMed rummage for the studies issued in the middle of 2014 and 2019

utilizing various combination of words, including the accompanying:

● Normal mixtures

● Flavonoids

● Bioflavonoid

● Neuroprotection

● Neurodegenerative illnesses

● Parkinson's sickness

● Alzheimer's infection

The review included only the relevant studies on the topic that used in vitro or in vivo models of AD

and PD.

Result and Discussion

Many medicinal plants and their secondary metabolites are affirmed with the ability to alleviate

the symptoms of degenerative disorders. The most important mechanisms identified, through which

phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in

ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and

monoamine oxidase inhibition and neurotrophic activities.

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Course Task 2: Journal articles on the advancement in treatment of Degenerative disorders Introduction Degenerative disorders are diseases that affect the central nervous system and peripheral nervous system. Depending on the site affected, the neuronal loss, gliosis or demyelination can lead to mot ...
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