Electro spun scaffolds for Tissue Engineering of Vascular Grafts Introduction ❖ The vascular grafts replacements have limited clinical success ❖ The primary causes of deaths is pathologies affecting small and medium sized blood vessels. ❖ The main cause of buildup of plaques below the intimal layer is Atherosclerosis. ❖ The peripheral vascular and artery diseases needs replacement of damaged major blood vessels and disease. ❖ The available replacements options for the transplants include autologous grafts, xenografts and synthetic vascular grafts or artificial prostheses. ❖ The alternative approach for creating new vascular grafts is tissue engineering. Structure vascular grafts  The human body native blood vessels consist of complex structure with distinct characteristics.  The arterial wall consist of three main layers, media, intima and the adventia.  The media, intima and adventitia are separated from each other by both the external and internal lamina  The confluent monolayer of EC prevents the clotting of blood, inflammation and infection of adjacent tissues in the lumen of blood vessels.  The concentric layer-wise structure of ECM,  The spatial organization and alignment of the EC and SMCs, and the interplay between the  The layering structure of the ECM, SMCs and EC both the spatial organization and alignment between the ECM and cell structures are critical factors when designing tissue engineered blood vesse ...
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