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Neisseriaceae 6

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Neisseriaceae • Includes the genera ─Neisseria, ─Kingella, ─Eikenella, • Sub group of Neisseria (Moraxella (Branhamella) catarrhalis 1 General Characteristics of Neisseria spp. • Aerobic, Gram-negative oval cocci • often arranged in pairs (diplococci) with adjacent sides flattened (like coffee beans) • slightly concave • Oxidase positive • Most catalase positive • Non motile • Acid form from oxidation of carbohydrates, not 2 from fermentation Species of Neisseria • Neisseria gonorrhoeae (Gonococcus): Causes disease gonorrhoea • Neisseria meningitidis (Meningiococcus): causes invasive meningiococcal diseases ✓ The two species are exclusively human pathogens 3 Species of Neisseria cont’d • Other species are common commensal of upper respiratory tract (oropharynx and nasopharynx) ─ Occasionally anogenital mucosal membranes 4 Neisseria gonorrhoeae (gonococcus) 5 General Overview of Neisseria gonorrhoeae • Readily transmitted by sexual contact • Gram-negative diplococci • Fastidious, and susceptible to cool temperatures, drying and fatty acids • Requires complex media pre-warmed to 35-37oC • Grow best in moist atmosphere supplemented with CO2 • Produce acid from glucose, but not from other sugars 6 Gonococcal Virulence Factors • Antiphagocytic capsule • fimbriated (piliated) cells • Outer membrane proteins •Por (porin protein) prevents phagolysosome fusion following phagocytosis • Promotes intracellular ...
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