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Alzheimer Disease

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Grossmont College
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Alzheimer’s disease (AD) Name: Zeena Kisso Instructor: Professor Steven Miller Institution: Grossmont College Course: Bio 230 Date: 11-27-2021 Alzheimer’s disease   Neurodegenerative disorder. The buildup of tau and amyloid in the brain is the major cause of AD development Figure 1: Amyloid plaques production in Alzheimer’s brain (ref2) Trouble doing familiar tasks Memory loss Disability to respond to environmental stimuli Symptoms of AD Changement in mood and behavior Disability to know who people are Disability to control languages, memory and thoughts Insulin signaling (A) and Glycolysis (B) Figure 1: insulin signaling in brain cells through IRS1; GluT 1;3;4 and INSR Figure B: Glycolytic enzymes implicated in the glycolysis of glucose into brain cells Ketolysis process Figure 2: Ketolytic enzymes implicated in the production of ketones Research article Article: Alzheimer’s disease alters oligodendrocytic glycolytic and Ketolytic gene expression. Department of Physiology and Development Biology, Brigham Young University, Provo, Utah, USA. Institution: Saito, E. R., Miller, J. B., Harari, O., Cruchaga, C., Mihindukulasuriya, K. A., Kauwe, J. S., & Bikman, B. T. (2021). Authors : Junior author: Erin R. Saito Senior author: Benjamin T. Bikman. This article is related to gene expression topic in Bio 230 Why??? 1- A strong correlation between the appearance and the progression of AD and the alteration of brain glucose metabolism. 2- The a ...
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