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NUCLEOTIDES
PART1:NUCLEOTIDES
1.UDP-glucoseisusedinsynthesis------------ ------------(glycogen)
2.UDP-glucoseandUDP-galactoseareusedinthesynthesisof…………..(cerebrosides)
3.CDP-diacylglycerolisuseinthesynthesisof……………and……………….( Phosp hoglycerides
andphosp holipid)
4.CMP-NANAcanbeusedtosynthesize……………(gangliosides)
5.Phosphoadenosinephosphosulphatecanbeusedtosynthesize……………….(sulphatides)
6.S-adenosylmethionine(SAM)isadonorofmethylgroupsin………….(Methylation
reaction)
7.Themetabolicrequirementforbothnucleotideandbasecanbemetbyboth…………..and
…………..(dietaryintake anddeNovos ynthesis)
8.ThemajorsourceofnucleotidesforsynthesisofDNA,RNA,enzymesandCo-factorsis
………(salvagepathway)
9.Innon-dividingcells,thebiosynthesisofindividualnucleotidesisnotextensivebecause
theneedfornucleotidescanbesatisfiedby…………..(salvageordietarysources)
10.Thedegradationofnucleicacidenteringthedigestivetractisimportanttotheoverall
…………..(nitrogenbalance)
11.Thepathwayforthebiosynthesisofnucleotidesfallinto…………and…………classes(de
novoan dsalvagep athway)
12.Thepathwayinwhichthenucleotidebasesareassembledfromsimplercompoundis
called……….(Denovop athway)
13.Theframeworkofthe………..isassembledfirstandattachedtotheribose(pyrimidine
)
14.Theframeworkfor……………….issynthesizepiecebypiecedirectlyontoaribose-based
structure(purine)
15.Thepathwayinwhichpreformedbasesarerecoveredandreconnectedtoariboseunitis
called…………….(Salvagepathway)
16.Denovosynthesisandmostsalvagepathwaysleadtothesynthesisof………..
(ribonucleotides)
17.Alldeoxyribonucleotidesaresynthesizedfromthecorresponding…………
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NUCLEOTIDESANDAMINOACIDMADEEASYBYNWAFORPETER(PROF)
(ribonucleotides)
18.Theactivatedsugarthatparticipatesinthedenovosynthesisandsalvageofpurines
andpyrimidinesis……………….(PRPP)
19.PRPPissynthesizedfrom……………and…………..by…………….(ATP,ribose-5-phosphate,
PRPPsynthetase)
20.AnothernameforPRPPsynthetaseis………………(ribosepho sphatepyrophosphokinase )
21.ThePRPPsynthetaseisactivatedby………….andinhibitedby……………(inorganic
phospha te,ADPandGDP)
22.Themajorsiteofpurinesynthesisis…………(liver)
23.Theatomsofthepurineringarecontributedby………..,………….,and………..(amino acid,
CO
2
andN
10
-formyltetrahydrofolate)
24.………….providesC-4,C-5andN-7andpurinering(glycine)
25.N
1
atomofpurineringcomesfrom……………..(aspartate)
26.N
3
andN9comefromtheamidegroupofthesidechainof…………(glutamine)
27.Theactivatedderivativesoftetrahydrofolatecontribute………..and………..(C
2
andC
8
)
28.CO
2
isthesourceof…………….inpurinesynthesis(C-6)
29.5
1
phosphoribosylamineissynthesizedfrom………(PRPPandglutamine)
30.Thecommittedstepenzymeinpurinenucleotidebiosynthesisis…………..(g lutamine
phosphoribosylpyriphosp ateamidotransferase)
31.Anenzymethatcatalysesthesynthesisofphosphoribosylamineis…………(glutamine
phosphoribosylpyrop hosph ateamidotransferase)
32.TheenzymeGPATisinhibitedby…………(purinenucleotides)
33.ThenumberofstepsthatleadtotheformationofIMP……..(10steps)
34.TheenzymethatcatalysestheringclosurebydehydrationintheformationofIMPis
called(IMPcyclohydrolase)
35.Theparentpurineis………….(IMP)
36.ThepathwayleadingtoAMPrequiresenergyintheformof…………andthatleadingto
GMPrequiresenergyinformof…………..(GTP,ATPrespectively)
37.AMPissynthesizedfromIMPbyinsertionofanaminogroupat…………..inplaceofthe

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