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SARS-COV-2 Life Cycle
SARS-CoV-2 is a large, enveloped, single-stranded RNA virus with a fine-experience. It entails sixteen
non-structural proteins (Nsp) which can be critical for viral replication and 4 different structural proteins
namely the spike, membrane, envelope and nucleocapsid, which mediate the cellular invasion and
immune response (Alsaadi and Jones, 2019; Gordon et al., 2020). sure structural proteins are
fantastically conserved among coronaviruses consisting of the Nsp12-RNA-established-RNA-polymerase
(RdRp) concerned in viral replication, even as others together with CoV-2 Spike (S)-protein, the main
SARS-CoV-2 antigenic structure, express a restrained genetic variability.
cellular invasion consists of the viral entry steps (receptor recognition, endocytosis and viral- membrane
fusion) and submit-entry steps (genomic RNA translation and replication, virion assembly, maturation, and
exocytosis). The host immune response is initiated as quickly as the type I interferon (IFN-I) reaction is
induced by means of intracellular genomic RNA. IFN-I release ends in the transcription of loads of
interferon-stimulated genes (ISGs) and to the recruitment of CD4 + T-helper cells, in addition accountable
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