Description
how do calcium channel blockers (CCBs) effect the electrophysiology of cardiac contractile cells on fig. attached
see fig. attached
Explanation & Answer
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The calcium-channel blockers represent a group of organic chemical
structures that share the ability to inhibit Ca2+ entry into excitable
cells. In cardiac contractile cells,
inhibition of Ca2+ entry blunts the ability of Ca2+ to serve as an
intracellular messenger. Thus, calcium-channel blockers have a negative inotropic effect on the
working myocardial cells of the atria and ventricles. Calcium-channel
blockers also have effects on impulse formation and conduction in some
regions of the heart.
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