Amino Acid Glutamine net charge

timer Asked: Sep 14th, 2015

Question description

The pKa of the α-carboxyl group of glutamine is 2.17, and the pKa of its α-amino group is is 9.13. Calculate the average net charge on glutamine if it is in a solution that has a pH of 8.90 (If the charge is positive, you do not need to enter a \" \" sign.

If the values for the pH and the pKa are more than 2 units apart, assume that the group is fully protonated or deprotonated. In this example, assume that the carboxyl group is fully deprotonated and is charged. Therefore, use the pKa of the amino group in the Henderson-Hasselbalch equation. Rearrange the Henderson-Hasselbalch equation to solve for [A–]/[HA]. Then solve for the fraction of NH3 groups (HA in the equation) in the protonated, and charged, form. The ionization we are concerned with is shown below for a general amino acid:

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