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Malaria
1. Using the list below, identify the stage of the drug discovery program described in the
news release.
Lead optimization stage
2. Briefly describe the type of organization pursuing the further investigation of the drug
(university, small start-up, CRO, PhRMA company).
A university which is Virginia Tech is pursuing further investigation with help from a
grant from the National Institutes of Health
3. What advantages over currently available therapies are being attributed to the new
discovery compound?
The compound targets the parasite's ability to produce isopentenyl pyrophosphate
(IPP), the key chemical building block that is used to make lipids and steroid hormones,
which are essential for cellular life, without IPP, the parasite will die.
4. What additional studies regarding the further development of the compound as a drug
are mentioned in the article?
The team is also collaborating with Max Totrov, a computational biologist at Molsoft
L.L.C. in San Diego, California, who will use computational methods to help improve the
potency and selectivity of the drug.
MRSA
1. Using the list below, identify the stage of the drug discovery program described in the
news release.
Repurposing (identifying a new therapeutic use for a previously known drug)
2. Briefly describe the type of organization pursuing the further investigation of the drug
(university, small start-up, CRO, PhRMA company).
Scientists from Emory University, specifically the lab of Cassandra Quave, an assistant
professor in Emory's Center for the Study of Human Health and in the School of
Medicine's Department of Dermatology.
3. What advantages over currently available therapies are being attributed to the new
discovery compound? The compound works not by killing the MRSA bacteria, but by
repressing a gene that allows the bacteria cells to communicate with one another.The
discovery may hold potential for new ways to treat and prevent antibiotic-resistant
infections, a growing international problem.
4. What additional studies regarding the further development of the compound as a drug
are mentioned in the article?
The Quave lab is now doing a...
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