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Prepare powerpoints on aspirin toxicity in paediatrics
APA format
Explanation & Answer
Attached.
Salicylate Toxicity
Pharmacokinetics and
Mechanism of Action
Pharmacokinetics I
▪ ASA and salicylic acid are absorbed within
15-30 minutes
▪ Salicylate is 90% bound to albumin
▪ An acidic pH promotes the movement of
salicylate into the tissues
Pharmacokinetics II
▪ After absorption ASA is de-acetylated
▪ Salicylate is either metabolized to gentisic
acid or bound to glycine or glucuronide, or
excreted as salicylate
▪ In tubular fluid, nonionized salicylate is
reabsorbed. Ionized salicylate cannot be
reabsorbed
Mechanism of Action
▪ Inhibition of COX-1 and COX-2
▪ Interference with oxidative pho...
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