aspirin toxicity in paediatrics, health and medicine homework help

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Prepare powerpoints on aspirin toxicity in paediatrics

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Salicylate Toxicity

Pharmacokinetics and
Mechanism of Action

Pharmacokinetics I
▪ ASA and salicylic acid are absorbed within
15-30 minutes
▪ Salicylate is 90% bound to albumin

▪ An acidic pH promotes the movement of
salicylate into the tissues

Pharmacokinetics II
▪ After absorption ASA is de-acetylated

▪ Salicylate is either metabolized to gentisic
acid or bound to glycine or glucuronide, or
excreted as salicylate
▪ In tubular fluid, nonionized salicylate is
reabsorbed. Ionized salicylate cannot be
reabsorbed

Mechanism of Action
▪ Inhibition of COX-1 and COX-2
▪ Interference with oxidative pho...


Anonymous
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