Description
Choose one article from a primary scientific literature resource which uses a microbe as a model organism/system and write a comprehensive summary of the study that answers the following: A. Why did the scientists perform the study? B. What was the hypothesis under investigation? C. What were the major results and did they support or negate the hypothesis? Which key techniques were used to achieve these results? D. Why are the results significant and do they point to further/future studies? In other words why does this article matter and what should or could be done next? E. Why did you choose this particular article to review? Was it interesting, informative, clearly written, or none of the above?
Explanation & Answer
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Journal Article Review: “Modeling Liver Cancer using Zebrafish: A Comparative
Oncogenomics Approach.”
The extensive record of zebrafish as a carcinogen toxicology model together with the
accessibility of many useful genetic instruments and vast genomic assets renders zebrafish an
appealing cancer model. The zebrafish is vulnerable to a variety of chemical carcinogens
(with a very small occurrence of unprompted cancer but a considerable amount of
tumorigenesis after the treatment of carcinogen) and churns out several neoplasm types in
different tissues demonstrating significant histopathologic similarity to mammalian and
human cancers. As a small aquarium fish, zebrafish can without difficulties be preserved in
high numbers, and all critical organs can be easily be assessed in a few histological parts.
Therefore, a study of zebrafish carcinogenesis is more economical, with better sta...
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