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I need a powerpoint presentation on SLE
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SYSTEMIC LUPUS ERYTHEMATOSUS
OUTLINE
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Definition
Epidemiology
Pathophysiology
Classification and diagnosis
Clinical Features
Lupus related syndromes
Treatment
Prognosis
DEFINITION
• Inflammatory autoimmune disorder
affecting multiple organ systems
characterized by the production of
autoantibodies directed against cell nuclei
and cytoplasmic antigens reflecting a global
loss of self-tolerance.
• SLE can affect any organ system, but it
mainly involves the skin, joints, kidneys,
blood cells, and nervous system ”
EPIDEMIOLOGY
• Prevalence influenced by age, gender, race,
and genetics
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Prevalence: 1:2000
Peak incidence 14-45 years
Black > White (1:250 vs. 1:1000)
Female predominance 10:1
HLA DR3 association, Family History
• Severity is equal in male and female
Epidem Cont:
• Genetic (HLA DR2&3 association)
– Abnormal immune response
• Environmental
– UV
– Viruses
– Hormones (Estrogen)
• Characterized by multisystem inflammation with
the generation of autoantibodies.
• Although the specific cause of SLE is unknown,
multiple factors are associated with the
development of the disease, including
– genetic, epigenetic, ethnic, immunoregulatory,
hormonal, and environmental factors.
– many immune disturbances, both innate and
acquired, occur in SLE
Pathogenesis – immunologic
abnormalities
• Central concept:
• Tolerance to self violated→→Autoantibodies
produced
Mechanism of autoantibody production and tissue injury in
lupus
B Cells in SLE
• Auto antigen specific B cells are found in
everyone
• Anergy and apoptosis prevents activation
In SLE : these B cells activate and produce
autoantibodies due to loss of self tolerance
Immune complex formation→→complement
consumption
T cells in SLE
• Probable central role in B cell activation
• Autoreactive T cell activation: failure of
– Thymic deletion
– Peripheral T cell anergy
– T suppresor cells function
• Futile activation results in impaired cellular
immunity
Mechanisms of tissue damage in
SLE
• Immune complex deposition in tissues and
vessels initiates inflammation leading to
damage
• Autoantibodies
• Cell mediated cy...
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