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provide 8 page document on diabetes in pregnancy. Use Bed side obstetrics and gynaecology. The work must be referenced, quality grammar is need, if you are poor in, kindly dont bid because i will withdraw.
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DIABETES MELLITUS IN PREGNANCY
Diabetes Mellitus in Pregnancy
Student’s Name
Institution of Affiliation
Date
1
DIABETES MELLITUS IN PREGNANCY
DIABETES MELLITUS IN PREGNANCY
CHO Metabolism in Pregnancy
Increase HPL and cortisol – relative insulin resistance in mother
Most marked in 3rd trimester
To balance these changes in normal pregnancy maternal pancreas secretes increased
amount of insulin to maintain CHO metabolism.
Result
➢ fall in fasting glucose level
➢ glucose levels higher than normal after CHO challenge
To foetus by facilitated diffusion across placenta. Level closely follows maternal level
Diabetes may complicate pregnancy either because:➢ Pre- existing insulin – dependent diabetes
➢ Impaired glucose tolerance during course of pregnancy
2
DIABETES MELLITUS IN PREGNANCY
Schematic diagram of metablic alterations in D. mellitus in late pregnancy (In absence
of appropriate therapy)
Foetus
Macrosomia
Mother
Increased
cortisol
➢
Increased
Insulin
resistance
Placenta
Anabolism
HPL
Glucose
synthesis
Progesterone
Increased
Foetal Insulin
Increased Fat
metabolism
Increased
maternal
blood
glucose
Oestrogen
Increase Foetal
blood glucose
Risk factors for development of diabetes in pregnancy
3
Lipogenesi
sSs
DIABETES MELLITUS IN PREGNANCY
Obesity (body mass index 30)
Family history
Previous baby > 4.5kg
Previous unexplained s...
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