bioinformatic and immunology

User Generated

snunq123n

Science

Description

I have attached homework related to bioinformatic and immunology course

Abbas, Lichtman and Pillai, Basic Immunology lists targets of monoclonal antibodies currently in clinical use.

Unformatted Attachment Preview

Bioinformatics Section The questions below relate to a protein annotated as 2I65_A in the NCBI protein database. Start by entering the annotation in the NCBI protein database via Entrez: www.ncbi.nlm.nih.gov/protein. 1) What is the function of this protein? 2) What superfamily does this protein belong to? Identify conserved domains of this protein. 3) What ligand does this protein bind? Click on the graphic that annotates binding site residues (below “query sequence and above “specific hits”) and on the page that comes up invoke Cn3D to visualize the structure. Use “show annotations panel” to highlight the ligand binding site. 4) List the amino acid residues that make up the ligand-binding site here: Go back to the “conserved domains” page and search for similar domain architectures. Some Bacilli have proteins with ~468 amino acids that contain a domain that is similar to the human domain mentioned above. There is an additional N-terminal domain in the bacillary proteins. 5) What is putative function of that additional N-terminal domain? Immunology Section Table 4.6 in Abbas, Lichtman and Pillai, Basic Immunology lists targets of monoclonal antibodies currently in clinical use. For each of the targets provide the following information: 1) Name of target, 2) Function of target, 3) Effect of the antibody (molecular mechanism), 4) Disease to be treated, 5) Side effect/precautions based on distribution and function of target 6) Generic and trade name of the antibody 7) Company producing the antibody. In footnotes, provide references for the information you enter. These can be literature references, patents or company datasheets. Add at least two more targets to you list and provide information item 1-7 for each.
User generated content is uploaded by users for the purposes of learning and should be used following Studypool's honor code & terms of service.

This question has not been answered.

Create a free account to get help with this and any other question!

Related Tags