In Module 3, Lecture 1, we learned about the four core principles of human subjects research (autonomy, beneficence, nonmaleficence, and justice) .For this assignment, consider what you read in Perusall activity by Johnston and Baylis (2004). Johnston and Baylis describe an older case of genome editing therapy for a disease called X-linked SCID (Severe Combined Immune Deficiency). Following a novel gene therapy for their X-linked SCID, two children in the clinical trial developed leukaemia. This article provides a case study of risks associated with genome editing for biomedical therapies. Johnston and Baylis article: "Gene Therapy:Two Steps Forward, one Step back" In at least 250 words (total): (1) Identify one of the four core principles of human subjects research at stake with this case. Explain why you think that the core principle you have chosen applies to this case. (2) Using the case describe in the Johnston and Baylis article, do the following: (a) Identify an ethical problem in the case. Explain why you believe that this is an ethical problem. (b) Identify ONE interested individual or institution (stakeholder) in this case. Explain why you believe that this individual or institution is a stakeholder in this case. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC419760/

Q1/ A 2 1/2-inch attack line that is 250 feet long has another 100 feet of 1 3/4-inch hose attached to its end. Attached to the end of the 1 3/4-inch hose is a nozzle that is flowing 95 gpm. Determine the total friction loss in the hose lay.Q2/ A pumper attached to a fire hydrant is supplying 500 gpm through 800 feet of dual 3-inch hoses (w/ 2 1/2-inch couplings) to a pumper at the fire scene. What is the friction loss in the hose lay?Q3/ A pumper attached to a fire hydrant is supplying 500 gpm through 800 feet of 4-inch hose to a pumper at the fire scene. What is the friction loss in the hose lay?Q4/ A pumper is supplying a 200 foot long, 3 1/2-inch blitz line that is equipped with a portable master stream nozzle with a 1 1/2-inch tip discharging at 80 psi. What is the pressure loss in this assembly?Q5/ A portable master stream device equipped with a 500 gpm fog nozzle is being supplied by a single 3-inch hose with 2 1/2-inch couplings that is 100 feet long. This hose is in turn being supplied by siamesed lines consisting of dual 2 1/2-inch hose, each 300 feet long. What is the pressure loss in the hose lay?these the Questions that I need help with it. Also, see the document to help you to answers these questions.