MN551 Disorders of White Blood Cells and Lymphoid Tissues

User Generated

Ybyn2018

Humanities

MN551-02: Advanced Physiology and Pathophysiology Across the Life Span

Purdue University

Description

Case Study 9

Disorders of White Blood Cells and Lymphoid Tissues

Max is a 60-year-old living in Iowa. For the 27 years, he has been working in the agricultural industry, particularly in the management of corn production. Recently he began to feel weak during work and tired easily. During the night he woke up sweating, and he often felt unusually warm during the day. Max was also surprised that, in spite of eating regularly, his weight was declining and his work pants were now too large for him. Upon physical examination, his physician noted his inguinal lymph nodes were swollen although Max said they were not sore. Subsequent laboratory tests confirmed follicular, non-Hodgkin lymphoma. Chemotherapy in conjunction with rituximab was immediately initiated.

  1. What are the key cellular differences between non-Hodgkin lymphoma and Hodgkin lymphoma?
  2. The early manifestations of non-Hodgkin lymphoma and Hodgkin lymphoma in lymphatic tissue appear differently. In terms of lymphatic presentation, how would these two diseases appear clinically?
  3. What are the pharmacologic properties of rituximab, and what is its mechanism of action on malignant cells?
  4. Outline the structure of lymph node parenchyma including the areas where B and T lymphocytes reside. Where did Max’s lymphoma arise?

Assignment Requirements:

Before finalizing your work, you should:

  • Ensure you have written at least four double-spaced pages.
  • be sure to read the Assignment description carefully (as displayed above);
  • consult the Grading Rubric (under the Course Resources) to make sure you have included everything necessary; and
  • utilize spelling and grammar check to minimize errors.
  • follow the conventions of Standard American English (correct grammar, punctuation, etc.);
  • be well ordered, logical, and unified, as well as original and insightful;
  • display superior content, organization, style, and mechanics; and
  • use APA 6th Edition format.
  • Requirements
    1. Make sure all of the topics in the case study have been addressed.
    2. Cite at least three sources—journal articles, textbooks, or evidenced-based websites—to support the content.
    3. All sources must have been written within five years.
    4. Do not use .com, Wikipedia, or up-to-date, etc., for your sources.

Tags: mn551
User generated content is uploaded by users for the purposes of learning and should be used following Studypool's honor code & terms of service.

Explanation & Answer

Hello buddy, kindly find your paper attached below. Let me know what you think. Thank you

Running Head: AN ANALYSIS OF LYMPHOMA

An Analysis of Lymphoma
Name
Institution

1

AN ANALYSIS OF LYMPHOMA

2

An Analysis of Lymphoma
During physical diagnosis, Hodgkin and non-Hodgkin lymphoma can be easily confused
because their symptoms are more or less the same. The patient experiences extreme fatigue, loss
of weight and fever, which are exactly the same symptoms that Max’s physical checkup pointed
to. It is only until a biopsy is conducted that the doctors can comfortably identify the type of
lymphoma the patient is suffering from, which is why the doctor asked for further laboratory tests
to be done on Max. Both cancers affect the lymphatic system of the body, and therefore the patient
starts experiencing the aforementioned symptoms. Based on Marginean et al. (2017) illustrations,
upon performing the biopsy, the main distinguishing factor between the two diseases is in the
presence of Reed-Sternberg cells in the cancerous cells. Hodgkin lymphoma, a type of cancer, is
distinctive because of the presence of Reed-Sternberg cells while the non-Hodgkin ones lack the
cells in the affected lymph nodes (Bowzyk et al.2018). Reed-Sternberg cells are mutated B
lymphocytes that are large because of their cellular strands, which are basically five times larger
than normal lymphocytes. These cells also have two nuclei which basically make them seem like
an eye, and they also have a lobular shape as the ones that were found in Max’s biopsy.
Also, in Hodgkin lymphoma, the cancerous cells are in most cases localized to single axial
group of nodes while the non-Hodgkin ones are different in the fact that they are involved most
frequently with multiple peripheral nodes. Further, the Hodgkin lymphoma cells are spread by
contiguity wh...


Anonymous
Excellent resource! Really helped me get the gist of things.

Studypool
4.7
Trustpilot
4.5
Sitejabber
4.4

Related Tags