Digestive, Urinary and Endocrine

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nvyrfgryyr

Writing

Description

Treatment options for acute and chronic diseases continue to advance in efforts to cure diseases or manage symptoms and improve quality of life. While working in healthcare, it is important to be able to research treatment options to understand the different treatments or questions patients may need to consider.

Select 1 disease directly related to one of the body systems reviewed in this module. Research and select a peer reviewed article written within the past 5 years discussing treatment options for the selected disease and write a 1-page (minimum) Annotated Bibliography. For annotated bibliographies, use standard APA format for the citations, then add a brief entry, including:

  • 2 to 4 sentences to summarize the main idea(s) of the source including a brief summary of the disease and treatment option(s).
  • 1 or 2 sentences to assess and evaluate the source including if this information is reliable and discuss if the source is objective or biased.
  • 1 or 2 sentences to reflect on the source including how this information can benefit a patient and your understanding of the selected disease.

Use APA formatting for your citations and references. For more information on APA, navigate to the Resources tab in this course.

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Explanation & Answer

Attached.

Alzheimer’s disease (AD) is a terminal progressive disorder and the most common type
of dementia without effective treatments. Earlier studies have shown that the disturbance of the
endoplasmic reticula calcium cations (Ca2+) through the overstimulation of the Ryanodine
receptors play a significant in the development of AD. This form of dementia affects 24-35
million people globally. Its incidence increases with age as it affects approximately six percent
of the population aged over 65 years. The pathogenesis of AD is supported by the Amyloid
cascade hypothesis that is commonly observed in suffering from AD. Calcium is an essential
second messenger in the nervous system as performs an important role in cellular functions such
as neurotransmitter action, learning and memory, and apoptosis. In 1978, it was proposed by Dr.
Zaven Khachaturian the Ca2+ hypothesis of Alzheimer’s disease that the disturbance in the
intracellular Ca2+ balance resulted in the pathogenesis of the condition and other age associated
brain disorders.
Ryanodine receptors are i...


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