Diptheria and their causes

Jun 29th, 2015
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C. diphtheriae that are lysogenic for phage b produce endotoxin only under conditions where iron has become limited; excess iron inhibits tox gene expression. 2 different classes of mutations in the coding sequence of a bacterial chromosomal gene called dtxR, which is not physically linked to phage b, lead to dramatic effects on Tox synthesis:Diphtheria is caused by strains of Corynebacterium diphtheriae that are lysogenic for a bacteriophage called "b".This phage carries a gene for an endotoxin (tox) that inhibits eukaryotic protein synthesis, and is a major virulence factor for this

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