Medicine powerpoint

Jun 29th, 2015
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Kaplan University
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Comprehensive power points in gynecology, internal medicine, ophthalmology, pharmacology, etc

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PEPTIC ULCER DISEASEDR ANN MULIOBJECTIVES1.2.3.4.5.6.7.DefinitionsNormal gastric physiologyEpidemiologyEtiology of PUDPathogenesis of PUDInvestigationsManagementINTRODUCTIONPeptic ulcers are defects inthe gastric or duodenalmucosa that extend throughthe muscularis mucosaNORMAL GASTRIC PHYSIOLOGYD cells- somatostatinThroughout the stomachParietal cell- HCL & IFChief cells-PepsinogenG cells- gastrinPNS: vagusSNS:celiacplexusGastroduodenal mucosal defenseRole of prostaglandins in gastric defense & repair regulate release of mucosal bicarbonate &mucus Inhibit parietal cell secretion Maintain mucosal blood flow Epithelial cell restitutionEPIDEMIOLOGYDU > GUDU occur in 6-15% of the western popGU occur later than DU with peakincidence 6th decadeEradication of H.pyroli has reducedrecurrence ratesEPIDEMIOLOGYIn the developing world 80% of the pop maybe infected with H.PYLORI by the age of 20yrscf to western world where it is 20-50%Two factors that lead to higher colonizationstates are:Poor social-economic statusLess educationEPIDEMIOLOGYTransmission of H.pyroli occurs fromperson to person through:Fecal-oral routeEtiology of PUDMost common etiologic factors1. H pylori infection2. Nonsteroidal anti-inflammatory drugs(NSAID) useOther causes of PUDSevere physiologic stressBurnsCNS traumaSurgerySevere medical illnessOther ca

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