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GastritisPeyman Adibi,MD.DefinitionThe term gastritis is used to denoteinflammation associated with mucosalinjuryGastritis is mostly a histological term thatneeds biopsy to be confirmedGastritis is usually due to infectious agents(such as Helicobacter pylori) andautoimmune and hypersensitivityreactions.DefinitionEpithelial cell damage and regeneration withoutassociated inflammation is properly referred toas "gastropathy.Gastropathy may be referred without histologicalevidence and just according to grossappearance in endoscopy or radiologyGastropathy is usually caused by irritants suchas drugs (eg, nonsteroidal antiinflammatoryagents and alcohol), bile reflux, hypovolemia,and chronic congestion.Grosshistologic correlation?Research evidenceAmong 98 patients with endoscopicmucosal changes attributed to gastritis, 27percent had a normal endoscopic biopsyspecimen; i.e. PPV of 73 percent or atleast 1 in four false positive diagnosisResearch evidenceamong 69 patients with a normalendoscopic appearance, 63 percent hadhistological evidence of gastritis. NPVequals to 27 percentClassificationAcute vs. chronicAcute refers to short term inflammation Acute refering to neurophilic infiltrateChronic referring to long standing forms Chronic referring to mononuclear cell infiltrateespecially lymphocyte and maccrophagesAnatomical siteCARDIAMUCOUSSECRETINGENDOCRINEBODY

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