Medicine powerpoint

Jun 29th, 2015
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Kaplan University
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Comprehensive power points in gynecology, internal medicine, ophthalmology, pharmacology, etc

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HEPATITISDR ANN KIBIRUVIRAL HEPATITISDEFINITIONHepatitis: inflammation of the liver caused by viruses,toxic substances or immunological abnormalities.VIRAL HEPATITISCommon:Hepatitis AHepatitis B +/- hepatitis D.Hepatitis CHepatitis ELess common:CytomegalovirusEpstein-Barr virusRare:Herpes simplexYellow feverHEPATITIS AMost prevalentResponsible for most forms of acute &benign hepatitisFulminant hep. failure is rare & occursmore often in adults than in children.VIROLOGY & ETIOLOGYdiscovered in 1973HAV is a 27nm, non enveloped, icosahedral,single stranded RNA virus classified inheparnavirus genus of the picornaviridae.CONT,Host: human & other primates.Transmission: fecal-oral route.Has an incubation period of approx. 4 wks.Its replication is limited to the liver.Risk fxt:Sexual & household contact with another person with Hep A.(10%)Homosexual activity in men (9%)Food or waterborne outbreaks (7%)Child or employee in a daycare center (4%)Injection drug use(3%)International travel (15%)EPIDEMIOLOGYOccurs worldwideCan occur sporadically or in an epidemic form.prevalent in low social economic areas(developing nations)- which lack adequatesanitation & poor hygienic practices, facilitatespread of the infectionPATHOGENESISReplication occurs within cytoplasm ofhepatocytes.Hepatocellular damage & destruction of infectedhepatocytes is mediated by HLA-restricted,

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