Medicine powerpoint

Jun 30th, 2015
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Kaplan University
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Comprehensive power points in gynecology, internal medicine, ophthalmology, pharmacology, etc

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HEPATITISDRANNKIBIRUVIRALHEPATITISDEFINITIONHepatitis:inflammationofthelivercausedbyviruses,toxicsubstancesorimmunologicalabnormalities.VIRALHEPATITISCommon: Hepatitis A Hepatitis B +/- hepatitis D. Hepatitis C Hepatitis ELess common: Cytomegalovirus Epstein-Barr virusRare: Herpes simplex Yellow feverHEPATITISA Mostprevalent Responsibleformostformsofacute&benignhepatitis Fulminanthep.failureisrare&occursmoreofteninadultsthaninchildren.VIROLOGY&ETIOLOGY discovered in 1973 HAV is a 27nm, nonenveloped, icosahedral,single stranded RNA virus classified inheparnavirus genus of the picornaviridae.CONT, Host: human & other primates. Transmission: fecal-oral route. Has an incubation period of approx. Its replication is limited to the liver.4 wks.EPIDEMIOLOGY Occursworldwide Can occur sporadically or in an epidemic form. prevalent in low social economic areas(developing nations)- which lack adequatesanitation & poor hygienic practices, facilitatespread of the infectionPATHOGENESIS Replicationoccurs within cytoplasm ofhepatocytes. Hepatocellular damage & destruction of infectedhepatocytes is mediated by HLA-restricted,HAV-specific CD8+ T lympocytes & NK cells.CLINICALMANIFESTATIONS Resultsin an acute, self-ltd illness; rarely leads tofulminant hepati

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