Respiratory Physiology & Neurobiology

Jun 30th, 2015
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Algoma University College
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Mutations of the PHOX 2B homeobox gene are associated with congenital central hypoventilation syndrome (CCHS). In patients with CCHS, the autonomous nervous system fails to generate adequate ventilation during sleep. This results in sleep-related ventilator dependency, from infancy and throughout life. In addition, CCHS patients lack ventilatory and perceptual chemosensitivity: they do not feel changes in blood oxygenation.

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Respiratory Physiology & Neurobiology 178 (2011) 357358Contents lists available at ScienceDirectRespiratory Physiology & Neurobiologyjournal homepage: central hypoventilation syndrome and desogestrel: A call for cautionAddendum to C. Straus, H. Trang, M.H. Becquemin, P. Touraine, T. Similowski,Chemosensitivity recovery in ondines curse syndrome under treatment withdesogestrel [Respir. Physiol. Neurobiol. 171 (2010) 171174]Christian Straus a,b, , Thomas Similowski a,baAssistance Publique - Hpitaux de Paris, Groupe Ho

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