The Medical Literature

Jun 30th, 2015
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University of Minnesota - Twin Cities
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You are a physician following a 35-year-old man who has had active Crohn disease for 8 years. The symptoms were severe enough to require resectional surgery 4 years ago, and despite treatment with sulfasalazine and metronidazole.

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Users' Guides to the Medical Literature: XII. How to Use Articles About Health-Related Quality of Life[The Medical Literature]Guyatt, Gordon H. MD, MSc; Naylor, C. David MD, MSc, DPhil;Juniper, Elizabeth MCSP, MSc; Heyland, Daren K. MD; Jaeschke,Roman MD, MSc; Cook, Deborah J. MD, MScFor the Evidence-Based Medicine Working Group. From the Departments of Clinical Epidemiology and Biostatistics (Drs Guyatt and Cook and Ms Juniper) andMedicine (Drs Guyatt, Heyland, Jaeschke, and Cook), McMaster University, Hamilton, Ontario, and the Institute for Clinical Evaluative Sciences and the Clinical Epidemiology Unit, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario (Dr Naylor).Users' Guides to the Medical Literature section editor: Drummond Rennie, MD, Deputy Editor (West), JAMA.CLINICAL SCENARIOYou are a physician following a 35-year-old man who has had active Crohn disease for 8 years. The symptoms were severe enough to require resectional surgery 4 years ago, and despite treatment with sulfasalazine and metronidazole, the patient has had active disease requiring oral steroids for the last 2 years. Repeated attempts to decrease the prednisone

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