Jun 30th, 2015
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Dominican Study Center of the Caribbean
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YKSBehavioralQuestionAnswerCase control studyA study that compares a group of people affected with adisease to a group without the disease (objective andretrospective)Odds ratio (ex: pts with COPD have higherodds of having a histroy of smoking)What measure can a case control study tell you?Cohort studyStudy that compares a given risk factor to a group without therisk factor (assesses whether risk factor increases likelihood ofdisease, objective and prospective)Relative risk (smokers have higher risk ofdeveloping COPD than nonsmokers)What measure can a cohort study tell you?Cross sectional study (doesn't establish arisk factor causality)Study that assesses frequency of disease (and risk factors) at aparticular point in timeDisease prevalenceWhat measure can a cross sectional study tell you?HeritabilityWhat does twin concordance study measure?Heritability and environmental influenceWhat does an adoption study measure?Phase ISmall number of healthy volunteers. Assesses safty, toxicity,and pharmacokinetics.Phase IISmall number of diseased patients. Assesses efficacy, dosingand adverse effects.Phase IIICompares the new treatment to the current standard of care.Uses a large number of patients.Meta-analysis (increases the power of thestudy)Pooled data from several studies integrated.Quality of individual studies and biasWhat is meta analysis limited by?Total cases in a given population at a giventime / total at

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