Stem cell-based anti-HIV gene therapy

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Human stem cell-based therapeutic intervention strategies for treating HIV infection have recently undergone a renaissance as a major focus of investigation. Unlike most conventional antiviral therapies, genetically engineered hematopoietic stem cells possess the capacity for prolonged self-renewal that would continuously produce protected immune cells to fight against HIV. A successful strategy therefore has the potential to stably control and ultimately eradicate HIV from patients by a single or minimal treatment. Recent progress in the development of new technologies and clinical trials sets.

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Virology 411 (2011) 260272Contents lists available at ScienceDirectVirologyj o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / y v i r oReviewStem cell-based anti-HIV gene therapyScott G. Kitchen a,c, Saki Shimizu a,b,c, Dong Sung An a,b,c,abcDivision of Hematology-Oncology, The David Geffen School of Medicine at University of California, Los Angeles, CA, USAUCLA school of Nursing, 615 Charles E Young Drive South, Los Angeles, CA 90095, USAThe UCLA AIDS Institute, 615 Charles E Young Drive South, Los Angeles, CA 90095, USAa r t i c l ei n f oArticle history:Received 15 December 2010Accepted 19 December 2010Available online 17 January 2011Keywords:HIVGene therapyStem cellsIntracellular immunizationGenetic immune therapya b s t r a c tHuman stem cell-based therapeutic intervention strategies for treating HIV infection have recently undergonea renaissance as a major focus of investigation. Unlike most conventional antiviral therapies, geneticallyengineered hematopoietic stem cells possess the capacity for prolonged self-renewal that would continuouslyproduce protected immune cells to ght against HIV. A successful strategy therefore has the potential to stablycontrol and ultimately eradicate HIV from patients by a single or minimal treatment. Recent progress in thedevelopment of new technologies and clinical trials sets the stage for the current generation of gene therapyapproaches to combat HIV infection

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