Patient Adherence and Medical Treatment Outcomes: A Meta-Analysis

Jul 4th, 2015
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Adherence is a factor in the outcome of medical treatment, but the strength and moderators of the adherence-outcome association have not been systematically assessed.

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http://journals.lww.com/lww-medicalcare/Abstract/2004/03000/Variations_in_Patients__Adherence_to_Medical.2.aspxVariations in Patients' Adherence to Medical Recommendations: A Quantitative Review of 50 Years of ResearchDiMatteo, M. Robin PhDAbstractBackground: The literature on patient adherence to treatment includes hundreds of empirical studies. A comprehensive examination of the findings requires the organization and quantification that is possible with meta-analysis.Objectives: The goals of this research are retrieval, compilation, and averaging of adherence rates in all published empirical studies from 1948 to 1998; assessment of variation according to sample characteristics, time period of publication, measurement method, disease, and regimen; and examination of the effects on adherence of patient demographic characteristics.Methods: We calculated a meta-analysis of 569 studies reporting adherence to medical treatment prescribed by a nonpsychiatrist physician, and 164 studies providing correlations between adherence and patients' age, gender, education, and income/socioeconomic status; group comparison and multiple regression analysis of moderators.Results: The average nonadherence rate is 24.8%. Controlling for intercorrelations among moderator variables, adherence is significantly higher in more recent and smaller studies and in those involving medication regimens and adult samples. The use of physical tests and self-report have respectively significant and

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